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Viral pathogenesis

HIV-1 Nef targets restriction factors

Nature Reviews Microbiology volume 13, page 661 (2015)Cite this article

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Restriction factors are host proteins that counteract viral replication and are usually inhibited by viral proteins. Usami et al. examined whether Nef targets an unidentified restriction factor by conducting a proteomic analysis of virions produced by cells infected with wild-type versus Nef-defective HIV-1. They identified SERINC3, a member of a family of transmembrane proteins, as being consistently present in Nef-defective virus but absent from wild-type HIV-1. In another study, Rosa et al. infected 31 human cell lines with wild-type versus Nef-defective HIV-1 and, using a global transcriptome analysis, correlated SERINC5 expression with Nef-dependent changes in viral infectivity. Notably, both groups then investigated the role of other SERINC proteins, with Usami et al. identifying SERINC5 and Rosa et al. identifying SERINC3 as being involved in the decrease in HIV-1 infectivity observed for Nef-defective HIV-1.

Nef targets ... SERINC3 and SERINC5, redirecting them from the plasma membrane to endosomes.

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References

  1. Rosa, A. et al. HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. Nature http://dx.doi.org/doi:10.1038/nature15399, (2015)

  2. Usami, Y. et al. SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. Nature http://dx.doi.org/10.1038/nature15400, (2015)

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Authors
  1. Cláudio Nunes-Alves
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Nunes-Alves, C. HIV-1 Nef targets restriction factors. Nat Rev Microbiol 13, 661 (2015). https://doi.org/10.1038/nrmicro3573

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