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Metabolism

A rapid satiety circuit

Nature Reviews Neuroscience volume 18, page 5 (2017)Cite this article

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Current models of hypothalamic function cannot account for the rapid induction of satiety: activation of arcuate nucleus pro-opiomelanocortin (POMC)-expressing neurons (ARCPOMC neurons) only reduces hunger after several hours. The authors showed that manipulation of a population of glutamatergic ARC neurons rapidly alters feeding in mice through a projection to the paraventricular hypothalamus, where their inputs converge with those of ARCPOMC neurons and agouti-related protein-expressing ARC neurons to mediate their effects.

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References

  1. Fenselau, H. et al. A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH. Nat. Neurosci. http://dx.doi.org/10.1038/nn.4442 (2016)

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  1. Katherine Whalley
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Whalley, K. A rapid satiety circuit. Nat Rev Neurosci 18, 5 (2017). https://doi.org/10.1038/nrn.2016.175

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