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Despite advances in HIV-1 treatment, half of all people living with HIV-1 experience HIV-associated neurocognitive disorders (HAND). Most of our understanding of HAND neuropathogenesis comes from studies of individuals with HIV-1 subtype B, which is responsible for a small proportion of global HIV-1 infections. By contrast, HIV-1 subtype C, which predominates in sub-Saharan Africa, affects many more people but remains poorly characterized, limiting our understanding of HAND at a global level.
In this Tools of the Trade article, Li Ji-An describes tiny recurrent neural networks, an interpretable and flexible modelling framework for discovering cognitive algorithms that govern biological decision-making.
In this Journal Club, N. Alex Cayco-Gajic discusses a study published in 2004 that modelled the pyloric network of the lobster stomatogastric ganglion.
In this Journal Club, Erfan Nozari discusses work detailing a simple, transparent algorithm for iEEG mapping of seizure onset zones and the emergent property of neural fragility at its core.
Artificial intelligence is rapidly advancing our mechanistic understanding of the shared structure between the brain and higher-order behaviours. In this Review, Mathis and Mathis synthesize state-of-the-art methods in joint modelling of neural activity and behaviour, emphasizing both the technical innovations and the conceptual frameworks driving progress in this rapidly evolving field.
Connectomics has delivered on its promise to map neuronal circuits at scale and at synaptic resolution. In this Review, Helmstaedter describes recent methodological achievements and remaining challenges in synaptic-resolution connectomics while synthesizing expanding connectomic mapping ambitions that include resolving local circuits of larger brains and screening of connectomes.
Methodological shortcomings have constrained studies describing the complex dynamics of interpersonal coordination, which is essential to human sociality. In this Perspective, Chidichimo et al. advance the case for the formal introduction of information-theoretic quantities and methods to overcome existing limitations in studies of naturalistic human interactions.
Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for abstract cognition.
