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Neurotransmission

Organelle blueprints unveiled

Nature Reviews Neuroscience volume 8, page 3 (2007)Cite this article

The authors first catalogued the repertoire of proteins that are expressed in highly purified synaptic vesicles by mass spectrometry. This proteomic approach identified many of the core proteins already known to be essential for synaptic vesicle function as well as a diverse set of other trafficking proteins associated with both endocytic and other exocytic pathways. Although some of the proteins identified might be contaminants, this finding indicates that synaptic vesicles are less isolated from other organelles of the secretory pathway than previously thought.

This study provides the most detailed description of a synaptic vesicle so far...

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References

ORIGINAL RESEARCH PAPER

  1. Takamori, S. et al. Molecular anatomy of a trafficking organelle. Cell 127, 831–846 (2006)

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FURTHER READING

  1. Jahn, R. & Scheller, R. H. SNAREs — engines for membrane fusion. Nature Rev. Mol. Cell Biol. 7, 631–643 (2006)

    Article  CAS  Google Scholar 

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  1. Associate Editor, Nature Reviews Molecular Cell Biology,

    James Pickett

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  1. James Pickett
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Pickett, J. Organelle blueprints unveiled. Nat Rev Neurosci 8, 3 (2007). https://doi.org/10.1038/nrn2060

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