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Circadian rhythms

Cycling vesicles for a cycling SCN

Nature Reviews Neuroscience volume 11, page 5 (2010)Cite this article

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The authors extracted proteins from mouse SCN at different circadian time points and determined their levels using a proteomic approach. This revealed 53 'spots' (∼6% of expressed proteins) showing clear changes in abundance between samples that were taken 12 hours apart. Some of these 53 proteins were isoforms, leaving 34 unique proteins identified that were under strong circadian control, including heat shock proteins, factors involved in cellular metabolism and factors involved in synaptic vesicle recycling.

The mRNAs encoding these proteins did not show circadian regulation, and these proteins had therefore not previously been recognized as being under clock control. This finding points to a role for post-transcriptional mechanisms in circadian regulation in the SCN, as had previously been shown in the liver.

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ORIGINAL RESEARCH PAPER

  1. Deery, M. J. et al. Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock. Curr. Biol. 19, 1–6 10.1016/j.cub.2009.10.024 (2009)

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  1. Leonie Welberg
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Welberg, L. Cycling vesicles for a cycling SCN. Nat Rev Neurosci 11, 5 (2010). https://doi.org/10.1038/nrn2799

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