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Neurogenetics

Probing genomic diversity in neurons

Nature Reviews Neuroscience volume 13, page 817 (2012)Cite this article

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Somatic mutations may contribute to neuronal functional diversity and the unexplained burden of neurological disease, but the extent of genomic diversity among individual neurons is unclear. Evrony et al. amplified the genomes of single neurons from the human brain and assessed the frequency with which somatic LINE-1 (L1) retrotransposon insertions occur. Some previous studies had found frequent L1 retrotransposition in the human brain, but Evrony et al. found < 1 somatic L1 insertion per neuron in the cortex and caudate nucleus, suggesting that L1 is not a major effector of neuronal diversity in these brain regions.

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ORIGINAL RESEARCH PAPER

  1. Evrony, G. D. et al. Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain. Cell 151, 483–496 (2012)

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  1. Darran Yates
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Yates, D. Probing genomic diversity in neurons. Nat Rev Neurosci 13, 817 (2012). https://doi.org/10.1038/nrn3402

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