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Learning and memory

Falsifying memory

Nature Reviews Neuroscience volume 14, page 591 (2013)Cite this article

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How false memories form is unclear. To begin to address this, Ramirez et al. aimed to create a false hippocampal memory in mice using optogenetics. They placed mice in a novel environment and labelled activated neurons in the dentate gyrus by the targeted expression of channelrhodopsin 2. The mice were then placed in a different environment and underwent fear conditioning while the neurons activated in the first environment were optogenetically reactivated. Subsequent placement of the mice into the first environment elicited a fear response, indicating that a false fear memory had been created.

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References

  1. Ramirez, S. et al. Creating a false memory in the hippocampus. Science 341, 387–391 (2013)

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  1. Darran Yates
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Yates, D. Falsifying memory. Nat Rev Neurosci 14, 591 (2013). https://doi.org/10.1038/nrn3581

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