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Neurodevelopmental disorders

The gut–microbiome–brain connection

Nature Reviews Neuroscience volume 15, page 65 (2014)Cite this article

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Hsiao et al. studied the offspring of the maternal immune activation (MIA) mouse model, which is used to investigate the link between maternal infection and ASDs. MIA offspring exhibited certain behavioural and neuropathological symptoms that are reminiscent of ASDs, and the authors found that, by 3 weeks of age, these mice also showed an increase in intestinal permeability and an abnormal intestinal cytokine profile that was characterized by high levels of the inflammatory marker interleukin-6.

alterations in commensal gut bacteria contribute to certain behavioural abnormalities in a mouse model of ASD

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References

  1. Hsiao, E. Y. et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell http://dx.doi.org/10.1016/j.cell.2013.11.024 (2013)

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  1. Monica Hoyos Flight
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Flight, M. The gut–microbiome–brain connection. Nat Rev Neurosci 15, 65 (2014). https://doi.org/10.1038/nrn3669

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