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Sensory systems

A touch of regulation

Nature Reviews Neuroscience volume 15, page 207 (2014)Cite this article

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The cell bodies of many cutaneous mechanosensory neurons reside in the dorsal root ganglion (DRG). The authors previously showed in DOR–green fluorescent protein (DORGFP) knock-in mice that most DORGFP-expressing (DORGFP+) DRG neurons have large-diameter cell bodies and express neurofilament heavy chain (NFH). Here, they found that Oprd1 mRNA, which encodes DOR, was concentrated in wild-type NFH+ large-diameter DRG neurons, and that the pattern of DOR radioligand binding in the wild-type mouse CNS was similar to the DORGFP expression pattern in knock-in mice, suggesting that DORGFP expression mimics native DOR expression.

Together, these data suggest that many DOR+ DRG neurons correspond to neurons that are touch-sensitive

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References

  1. Bardoni, R. et al. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron http://dx.doi.org/10.1016/j.neuron.2014.01.044 (2014)

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Authors
  1. Darran Yates
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Yates, D. A touch of regulation. Nat Rev Neurosci 15, 207 (2014). https://doi.org/10.1038/nrn3721

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