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Metabolism

Sugar on the brain

Nature Reviews Neuroscience volume 15, page 563 (2014)Cite this article

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Because obesity and ageing are risk factors for type 2 diabetes, the authors compared hypothalamic expression levels of several genes in mice fed a high-fat diet (HFD) versus those fed a normal chow diet, middle-aged versus young mice, and mice fed ad libitum versus calorie-restricted mice. This revealed that HFD-fed mice and middle-aged mice had higher hypothalamic Tgfb1 mRNA expression (mainly in astrocytes) than their comparison groups. By contrast, Tgfb1 mRNA levels were reduced in calorie-restricted mice.

high levels of TGFβ1 in the brain seem to induce a pre-diabetic state

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References

  1. Yan, J. et al. Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response. Nature Med. http:dx.doi.org/10.1038/nm.3616 (2014)

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Authors
  1. Leonie Welberg
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Grayson, B. E., Seeley, R. J. & Sandoval, D. A. Wired on sugar: the role of the CNS in the regulation of glucose homeostasis. Nature Rev. Neurosci. 14, 24–37 (2013)

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Welberg, L. Sugar on the brain. Nat Rev Neurosci 15, 563 (2014). https://doi.org/10.1038/nrn3812

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