Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Genes and disease

Schwann cells keep axons healthy

Nature Reviews Neuroscience volume 15, page 632 (2014)Cite this article

Subjects

Charcot-Marie-Tooth disease 1A (CMT1A) is an inherited neuropathy caused by duplication of the gene encoding peripheral myelin protein 22 (PMP22). In this study, PMP22 duplication in rodents caused defects in Schwann cell differentiation in early postnatal development, which persisted into adulthood. This abnormal Schwann cell phenotype could be rescued by axonal overexpression of neuregulin-1 (NRG1) or by treatment with soluble NRG1 in early postnatal stages. These data suggest that there is a temporal window for correct Schwann cell differentiation that is vital to prevent the neuropathy observed in CMT1A.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Fledrich, R. et al. Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nature Med. http://dx.doi.org/10.1038/nm.3664 (2014)

Download references

Authors
  1. Sian Lewis
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lewis, S. Schwann cells keep axons healthy. Nat Rev Neurosci 15, 632 (2014). https://doi.org/10.1038/nrn3831

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrn3831

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing