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Cortical plasticity

A critical role for Clock

Nature Reviews Neuroscience volume 16, page 247 (2015)Cite this article

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Circadian fluctuations in the expression of 'molecular clock' genes occur in all brain regions, including the cortex, but little is known about the roles of these circadian genes outside the suprachiasmatic nucleus. The authors found that oscillations in the expression of several key circadian genes emerged with the development of cortical circuitry and the onset of the critical period in the primary visual cortex (V1) in mice.

the loss of Clock expression delayed the onset of critical period plasticity

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References

  1. Kobayashi, Y., Ye, Z. & Hensch, T. K. Clock genes control cortical critical period timing. Neuron http://dx.doi.org/10.1016/j.neuron.2015.02.036 (2015)

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  1. Katherine Whalley
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Whalley, K. A critical role for Clock. Nat Rev Neurosci 16, 247 (2015). https://doi.org/10.1038/nrn3953

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