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Learning and memory

Demethylated learning

Nature Reviews Neuroscience volume 16, page 510 (2015)Cite this article

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Lysine-specific histone demethylase 1A (LSD1) targets histone H3 lysines to regulate transcription. Wang et al. found that, in vitro, a neuronal LSD1 isoform (LSD1n) targeted a different substrate: histone H4 lysine 20 (H4K20). Lsd1n knockout (Lsd1n−/−) mouse neurons showed increased H4K20 methylation and impaired gene transcription following neuronal activity, and Lsd1n−/− mice showed deficits in two learning and memory tasks. Thus, LSD1n may promote activity-induced transcription in neurons and thereby regulate memory formation.

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References

  1. Wang, J. et al. LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nat. Neurosci. http:/dx.doi.org/10.1038/nn.4069 (2015)

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  1. Darran Yates
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Yates, D. Demethylated learning. Nat Rev Neurosci 16, 510 (2015). https://doi.org/10.1038/nrn4016

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