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Risk factors

Does uric acid level affect renal and cardiovascular risk?

Nature Reviews Nephrology volume 6, page 562 (2010)Cite this article

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Two papers published in the August 2010 issue of the American Journal of Kidney Diseases provide further evidence that hyperuricemia is a risk factor for renal and cardiovascular disease.

Many studies have shown that high serum uric acid level is an independent risk factor for cardiovascular and renal disease, and epidemiological studies have indicated that hyperuricemia might have a causal role in kidney disease. However, as hyperuricemia often occurs in patients with other risk factors for chronic kidney disease (CKD) and cardiovascular disease, including hypertension, diabetes and proteinuria, the independence of the association is unclear.

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ORIGINAL RESEARCH PAPERS

  1. Bellomo, G. et al. Association of uric acid with changes in kidney function in healthy normotensive individuals. Am. J. Kidney Dis. 56, 264–272 (2010)

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  2. Wen, C. P. et al. Is high serum uric acid a risk marker or a target for treatment? Examination of its independent effect in a large cohort with low cardiovascular risk. Am. J. Kidney Dis. 56, 273–288 (2010)

    Article  CAS  Google Scholar 

  3. Goicoechea, M. et al. Effect of allopurinol in chronic kidney disease progression and cardiovascular risk. Clin. J. Am. Soc. Nephrol. 5, 1388–1393 (2010)

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  1. Rebecca Ireland
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Ireland, R. Does uric acid level affect renal and cardiovascular risk?. Nat Rev Nephrol 6, 562 (2010). https://doi.org/10.1038/nrneph.2010.118

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