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Study reveals link between autonomic imbalance and kidney disease

Nature Reviews Nephrology volume 6, page 631 (2010)Cite this article

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New findings revealing an association between heart rate variability (HRV) and the development of renal impairment suggest that autonomic dysfunction may contribute to kidney disease, according to Daniel Brotman and colleagues. “Our findings might not change patient management immediately, but further understanding of the mechanisms involved might lead to new interventional strategies or to investigations of whether current treatment strategies already alter these pathways”, explains Brotman.

The researchers found that high resting heart rate and low HRV were associated with the development of renal impairment, even after adjustment for known risk factors. Fully adjusted hazard ratios for the development of end-stage renal disease were 1.98 (95% CI 1.45–2.70) among individuals in the highest heart-rate quartile and 1.56 (95% CI 1.14–2.14) among individuals in the lowest HRV quartile.

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ORIGINAL RESEARCH PAPER

  1. Brotman, D. J. et al. Heart rate variability predicts ESRD and CKD-related hospitalization. J. Am. Soc. Nephrol. 21, 1560–1570 (2010)

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  1. Susan J. Allison
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Allison, S. Study reveals link between autonomic imbalance and kidney disease. Nat Rev Nephrol 6, 631 (2010). https://doi.org/10.1038/nrneph.2010.135

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