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Polycystic kidney disease

Angiogenic growth factor level correlates with structural and functional changes in ADPKD

Nature Reviews Nephrology volume 7, page 3 (2011)Cite this article

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Autosomal dominant polycystic kidney disease (ADPKD) in children is characterized by renal cysts and renal volume expansion, often in the absence of renal dysfunction. A study has now demonstrated the potential role of angiogenic growth factors in the progression of cyst development and kidney dysfunction in these patients. “We are hopeful that our studies will ultimately result in new therapies for ADPKD, in particular interventions that will effectively slow renal disease progression in young patients,” says corresponding author Berenice Reed.

We hypothesized that altered expression of these angiogenic growth factors might occur...

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ORIGINAL RESEARCH PAPER

  1. Reed, B. Y. et al. Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease. Kidney Int. doi:10.1038/ki.2010.355

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  1. Susan J. Allison
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Allison, S. Angiogenic growth factor level correlates with structural and functional changes in ADPKD. Nat Rev Nephrol 7, 3 (2011). https://doi.org/10.1038/nrneph.2010.160

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  • DOI: https://doi.org/10.1038/nrneph.2010.160

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