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Hypertension: The Symplicity of renal denervation for patients with treatment-refractory hypertension

Nature Reviews Nephrology volume 7, page 64 (2011)Cite this article

A new study published in The Lancet has demonstrated that catheter-based renal sympathetic denervation is a viable treatment option for patients with uncontrolled high blood pressure. Short bursts of low-power radiofrequency to the main renal arteries can reduce sympathetic activity and renin release, leading to a decrease in blood pressure and preventing sequelae of hypertension.

The Symplicity HTN-2 investigators assessed the safety and effectiveness of renal denervation in patients with a systolic blood pressure ≥160 mmHg (≥150 mmHg in patients with type 2 diabetes) on three or more antihypertensive therapies. In total, 106 patients from 24 centers were randomly assigned to either undergo renal denervation together with previous treatment or to maintain previous treatment alone (control group). Office-based measurements of blood pressure, serum creatinine concentration, cystatin C concentration, and urine albumin-to-creatinine ratio were assessed at 1 month, 3 months, and 6 months.

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ORIGINAL RESEARCH PAPER

  1. Symplicity HTN-2 Investigators. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376, 1903–1909 (2010)

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Authors
  1. Helene Myrvang
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Myrvang, H. Hypertension: The Symplicity of renal denervation for patients with treatment-refractory hypertension. Nat Rev Nephrol 7, 64 (2011). https://doi.org/10.1038/nrneph.2010.181

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  • DOI: https://doi.org/10.1038/nrneph.2010.181

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