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Transplantation

Initially intensified mycophenolate dosing reduces rejection rates in de novo renal transplant recipients

Nature Reviews Nephrology volume 7, page 488 (2011)Cite this article

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A prospectively planned meta-analysis based on two randomized trials has shown that de novo renal transplant recipients treated with an initially intensified regimen of enteric-coated mycophenolate sodium (EC-MPS) have a lower rate of acute rejection than patients treated with a standard regimen.

“Approximately half of patients treated with ciclosporin and standard mycophenolate doses have exposure below the recommended target dose,” says investigator Klemens Budde. “Patients with low exposure in the first month are known to have an increased risk of rejection.”

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ORIGINAL RESEARCH PAPER

  1. Budde, K. et al. Improved rejection prophylaxis with an initially intensified dosing regimen of enteric-coated mycophenolate sodium in de novo renal transplant recipients. Transplantation doi:10.1097/TP.0b013e318223d7f3

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Authors
  1. Helene Myrvang
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Myrvang, H. Initially intensified mycophenolate dosing reduces rejection rates in de novo renal transplant recipients. Nat Rev Nephrol 7, 488 (2011). https://doi.org/10.1038/nrneph.2011.103

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  • DOI: https://doi.org/10.1038/nrneph.2011.103

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