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Polycystic kidney disease

Imaging without contrast to improve safety in patients with impaired renal function

Nature Reviews Nephrology volume 7, page 184 (2011)Cite this article

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A new study has demonstrated the feasibility of measuring total renal volume without the need for contrast medium.

In patients with autosomal dominant polycystic kidney disease (ADPKD), total renal volume is a measure of disease progression that is commonly assessed by CT and MRI. However, a disadvantage of these techniques is that they often use contrast medium, which can be nephrotoxic, especially in patients with impaired renal function. Also, the kidney contours on images have to be manually traced, which is a labor-intensive and subjective process. Therefore, Renzo Mignani and colleagues developed a semi-automated method utilizing axial T2-weighted MRI without contrast medium, which was tested for its accuracy in a cohort of patients with ADPKD.

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ORIGINAL RESEARCH PAPER

  1. Mignani, R. et al. Assessment of kidney volume in polycystic kidney disease using magnetic resonance imaging without contrast medium. Am. J. Nephrol. 33, 176–184 (2011)

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  1. Helene Myrvang
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Myrvang, H. Imaging without contrast to improve safety in patients with impaired renal function. Nat Rev Nephrol 7, 184 (2011). https://doi.org/10.1038/nrneph.2011.19

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