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Mineral metabolism

Sevelamer slows calcification and reduces levels of AGEs

Nature Reviews Nephrology volume 7, page 183 (2011)Cite this article

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A randomized trial has shown that sevelamer decreases the risk of calcification and reduces the accumulation of advanced glycation end products (AGEs) in patients undergoing maintenance hemodialysis.

High serum levels of phosphorus, calcium, and calcium–phosphorus product are associated with increased risk of arterial calcification and cardiovascular mortality. In addition, high levels of circulating AGEs are common in uremic patients and have been related to cardiovascular disease. Sevelamer is a mineral-free phosphate binder that has been shown to decrease serum levels of phosphorus and parathyroid hormone in dialysis patients, and to attenuate the progression of calcification. Takatoshi Kakuta et al. compared the effects of sevelamer and calcium carbonate on the progression of arterial calcification and on plasma concentrations of the AGE pentosidine.

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ORIGINAL RESEARCH PAPER

  1. Kakuta, T. et al. Effect of sevelamer and calcium-based phosphate binders on coronary artery calcification and accumulation of circulating advanced glycation end products in hemodialysis patients. Am. J. Kidney Dis. 57, 422–431 (2011)

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  1. Helene Myrvang
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Myrvang, H. Sevelamer slows calcification and reduces levels of AGEs. Nat Rev Nephrol 7, 183 (2011). https://doi.org/10.1038/nrneph.2011.21

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  • DOI: https://doi.org/10.1038/nrneph.2011.21

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