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Transplantation

Alemtuzumab induction is safe for renal transplant recipients

Nature Reviews Nephrology volume 7, page 362 (2011)Cite this article

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Alemtuzumab is as safe and effective as commonly used induction agents in preventing biopsy-confirmed acute rejection, reports a study published in the New England Journal of Medicine.

Antibody induction therapy enables early glucocorticoid withdrawal in renal transplant recipients. The most frequently used induction agents in the US have been rabbit antithymocyte globulin and basiliximab. Alemtuzumab is a newer agent developed in the UK. “Early results with alemtuzumab in the US were highly variable and created a lot of concerns about infectious complications, rejection, and how well patients did,” says investigator Michael Hanaway on behalf of the INTAC Study Group, who carried out the latest study following excellent results with the use of alemtuzumab from a 2005 study.

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ORIGINAL RESEARCH PAPER

  1. Hanaway, M. J. et al. Alemtuzumab induction in renal transplantation. N. Engl. J. Med. 364, 1909–1919 (2011)

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  1. Helene Myrvang
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Myrvang, H. Alemtuzumab induction is safe for renal transplant recipients. Nat Rev Nephrol 7, 362 (2011). https://doi.org/10.1038/nrneph.2011.66

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  • DOI: https://doi.org/10.1038/nrneph.2011.66

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