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Transplantation

A urinary signature for renal allograft fibrosis

Nature Reviews Nephrology volume 8, page 373 (2012)Cite this article

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Measurement of mRNAs in urinary cells may enable the noninvasive diagnosis of renal allograft fibrosis, according to new research. Anglicheau and colleagues examined mRNA levels in urine specimens from 114 renal allograft recipients (48 with renal fibrosis and 66 without). They developed a four-gene model that predicted the presence of allograft fibrosis with a sensitivity of 77.3% and a specificity of 87.5% in an independent validation subset.

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ORIGINAL RESEARCH PAPER

  1. Anglicheau, D. et al. Discovery and validation of a molecular signature for the noninvasive diagnosis of human renal allograft fibrosis. Transplantation doi:10.1097/TP.0b013e31824ef181

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A urinary signature for renal allograft fibrosis. Nat Rev Nephrol 8, 373 (2012). https://doi.org/10.1038/nrneph.2012.104

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