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Transplantation

Steroid avoidance in pediatric transplant patients is safe

Nature Reviews Nephrology volume 8, page 434 (2012)Cite this article

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Steroid avoidance is not associated with an increased risk of clinical rejection in pediatric kidney transplant recipients, show investigators of a randomized, prospective, multicenter trial. “The design of this trial was based on very exciting single-center data where we used extended daclizumab to provide additional immunosuppression in the first 6 months after transplantation while completely eliminating steroid use”, says researcher Minnie Sarwal. “This approach was a departure from usual care in children where steroid withdrawal was being practiced either very selectively, or not at all.”

...the growth rate for children aged <5 years was significantly higher in the steroid-free than in the steroid-based group

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ORIGINAL RESEARCH PAPERS

  1. Sarwal, M. M. et al. Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up. Am. J. Transplant. doi:10.1111/j.1600-6143.2012.04145.x

  2. Naesens, M. et al. Subclinical inflammation and chronic renal allograft injury in a randomized trial on steroid avoidance in pediatric kidney transplantation. Am. J. Transplant. doi:10.1111/j.1600-6143.2012.04144.x

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Authors
  1. Helene Myrvang
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Myrvang, H. Steroid avoidance in pediatric transplant patients is safe. Nat Rev Nephrol 8, 434 (2012). https://doi.org/10.1038/nrneph.2012.130

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