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Chronic kidney disease

Association of chronic kidney disease with adverse outcomes in the absence of hypertension and diabetes

Nature Reviews Nephrology volume 8, page 611 (2012)Cite this article

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Chronic kidney disease (CKD) is a strong predictor of mortality and end-stage renal disease (ESRD), even in the absence of diabetes and/or hypertension, say the authors of two large-scale meta-analyses. “Our findings suggest that several major health outcomes, including ESRD and death, are increased in individuals with chronic kidney disease, irrespective of the cause of their impaired kidney function”, Caroline Fox and colleagues state in their paper.

CKD often coexists with comorbidities. Hypertension is both a cause and a consequence of CKD and is the most common cardiovascular risk factor associated with CKD. On the other hand, diabetes is the leading cause of CKD in developed countries. Outcomes for individuals with CKD and hypertension and/or diabetes are known to be poor; however, the extent to which these comorbidities modify the association of CKD with adverse outcomes is not well understood. The two meta-analyses, performed by members of the Chronic Kidney Disease Prognosis Consortium, aimed to explore the associations of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and ESRD risk according to hypertensive and diabetes status.

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ORIGINAL RESEARCH PAPERS

  1. Mahmoodi, B. K. et al. Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis. Lancet doi:10.1016/S0140-6736(12)61272-0

  2. Fox, C. S. et al. Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis. Lancet doi:10.1016/S0140-6736(12)61350-6

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  1. Susan J. Allison
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Allison, S. Association of chronic kidney disease with adverse outcomes in the absence of hypertension and diabetes. Nat Rev Nephrol 8, 611 (2012). https://doi.org/10.1038/nrneph.2012.199

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