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Glomerular diseases

MPO CD4+ T-cell epitope induces glomerulonephritis

Nature Reviews Nephrology volume 8, page 612 (2012)Cite this article

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A study has identified an immunodominant CD4+ T-cell epitope of myeloperoxidase (MPO) that induces focal necrotizing glomerulonephritis (FNGN) in immunized mice. Transfer of MPO409–428-specific CD4+ T cells into mice induced FNGN when MPO was deposited in glomeruli by several mechanisms, including neutrophil recruitment by transfer of anti-MPO antibodies. The presence of MPO409–428 in glomeruli, with antigen-specific CD4+ T cells, led to functional injury. In addition, biologically active anti-MPO antibodies were detected in MPO409–428-immunized mice.

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ORIGINAL RESEARCH PAPER

  1. Ooi, J. D. et al. The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.1210147109

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MPO CD4+ T-cell epitope induces glomerulonephritis. Nat Rev Nephrol 8, 612 (2012). https://doi.org/10.1038/nrneph.2012.202

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