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Transplantation

Pre-emptive CMV therapy versus universal CMV prophylaxis in renal transplant recipients

Nature Reviews Nephrology volume 8, page 614 (2012)Cite this article

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A new study reports that of the two main strategies for the prevention of cytomegalovirus (CMV) in renal transplant recipients, pre-emptive treatment of CMV may be associated with better outcomes than universal CMV antiviral prophylaxis.

Protocol biopsies were performed in 55 patients at 3 years after transplantation. At this point, interstitial fibrosis and tubular atrophy was more common in biopsy samples from the prophylaxis group than in samples from the pre-emptive therapy group (38% versus 19%, respectively).

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ORIGINAL RESEARCH PAPER

  1. Reischig, T. et al. Long-term outcomes of pre-emptive valganciclovir compared with valacyclovir prophylaxis for prevention of cytomegalovirus in renal transplantation. J. Am. Soc. Nephrol. doi:10.1681/ASN.2012010100

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  1. Rebecca Kelsey
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Kelsey, R. Pre-emptive CMV therapy versus universal CMV prophylaxis in renal transplant recipients. Nat Rev Nephrol 8, 614 (2012). https://doi.org/10.1038/nrneph.2012.210

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  • DOI: https://doi.org/10.1038/nrneph.2012.210

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