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Transplantation

WISE contributes to renal allograft dysfunction

Nature Reviews Nephrology volume 9, page 64 (2013)Cite this article

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Wnt-modulator in surface ectoderm (WISE) promotes tubular atrophy and interstitial fibrosis, say researchers. Qian et al. showed that WISE mRNA was expressed in normal rat kidneys and in rat renal transplants. In a rat model of chronic allograft dysfunction, treatment with an anti-WISE neutralizing antibody improved graft function, increased kidney β-catenin levels, attenuated glomerular and interstitial injury, and reduced proteinuria, renal injury biomarker levels, kidney infiltration of macrophages and T cells, and the expression of immune response and profibrotic genes.

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ORIGINAL RESEARCH PAPER

  1. Qian, X. et al. Inhibition of WISE preserves renal allograft function. J. Am. Soc. Nephrol. doi:10.1681/ASN.2012010012

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WISE contributes to renal allograft dysfunction. Nat Rev Nephrol 9, 64 (2013). https://doi.org/10.1038/nrneph.2012.267

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