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Podocyte biology

Protein network involved in maintaining kidney permeability

Nature Reviews Nephrology volume 9, page 64 (2013)Cite this article

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A study published in the Journal of Clinical Investigation reports on a protein network that has a key role in generating and maintaining the glomerular filtration barrier (GFB) in the kidney.

First, the researchers—in collaboration with Pietro De Camilli—showed that podocyte-selective knockout of the dynamin 1 and dynamin 2 genes in mice led to effacement of foot processes, severe proteinuria and kidney failure. Next, they demonstrated that knockout mice lacking either synaptojanin 1 or the three endophilin proteins (which are all key functional partners of dynamin at neuronal synapses) were macroscopically normal at birth but had impaired neurological function and an underdeveloped GFB that resulted in severe proteinuria.

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ORIGINAL RESEARCH PAPER

  1. Soda, K. et al. Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J. Clin. Invest. doi:10.1172/JCI65289

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Authors
  1. Rebecca Kelsey
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Kelsey, R. Protein network involved in maintaining kidney permeability. Nat Rev Nephrol 9, 64 (2013). https://doi.org/10.1038/nrneph.2012.271

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