The disease manifestations and outcomes in lupus nephritis are exceptionally heterogeneous. In particular, some ethnic populations are disproportionately affected by the most severe forms of the disease. A new study exploring NF-κB dysregulation and its associated genetic variants might help explain the link between ancestry and outcomes in lupus nephritis.
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Bomback, A., Gharavi, A. Ancestry, genetic risk and health disparities. Nat Rev Nephrol 9, 699–700 (2013). https://doi.org/10.1038/nrneph.2013.210
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DOI: https://doi.org/10.1038/nrneph.2013.210
