Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Acute kidney injury

Critical role of complement in EndMT

Nature Reviews Nephrology volume 10, page 183 (2014)Cite this article

Subjects

Complement has a critical role in the induction of endothelial–mesenchymal transition (EndMT) during renal ischaemia–reperfusion injury, according to new findings. “These data shed light on the pathogenic factors that regulate this particular form of endothelial dysfunction, which has an important role in the regulation of renal fibrosis,” says researcher Giuseppe Castellano.

Ischaemia–reperfusion injury is a common cause of acute kidney injury (AKI) and is associated with substantial morbidity in kidney transplant recipients. “Endothelial cell damage and renal fibrosis are pivotal in the induction and extension phases of acute graft injury during ischaemia–reperfusion injury,” explains Castellano. “However, the factors that contribute to endothelial damage in ischaemia–reperfusion injury are poorly understood.”

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Curci, C. et al. Endothelial-to-mesenchymal transition and renal fibrosis in ischaemia/reperfusion injury are mediated by complement anaphylatoxins and Akt pathway. Nephrol. Dial. Transplant. 10.1093/ndt/gft516

Download references

Authors
  1. Ellen F. Carney
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Carney, E. Critical role of complement in EndMT. Nat Rev Nephrol 10, 183 (2014). https://doi.org/10.1038/nrneph.2014.19

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrneph.2014.19

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing