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Glomerular disease

New screen predicts FSGS recurrence

Nature Reviews Nephrology volume 10, page 675 (2014)Cite this article

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Researchers have developed a novel antibody screen to estimate the risk of recurrence of focal segmental glomerulosclerosis (FSGS)—a major cause of accelerated graft loss—prior to kidney transplantation. “The inability of clinicians to predict FSGS recurrence is frustrating and adds to the organ shortage problem,” explains author Minnie Sarwal.

To identify specific autoantibodies against glomerular proteins that might drive kidney injury in FSGS, Sarwal and colleagues profiled the pretransplant sera of 20 patients with primary FSGS against 9,000 human proteins. “Analysis of the highly coordinated autoantibody profiles in recurrent FSGS led us to uncover disease-causing proteins or target antigens,” says Sarwal.

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References

  1. Delville, M. et al. A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation. Sci. Transl. Med. 6, 256ra136 (2014).

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  1. Jessica K. Edwards
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Edwards, J. New screen predicts FSGS recurrence. Nat Rev Nephrol 10, 675 (2014). https://doi.org/10.1038/nrneph.2014.195

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