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Sickle cell trait increases the risk of chronic kidney disease

Nature Reviews Nephrology volume 11, page 65 (2015)Cite this article

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Data regarding the health consequences of sickle cell trait (SCT)—including a potential relationship with impairment of renal function— are conflicting. A large prospective population-based study by Alexander Reiner and colleagues has now shown that SCT is associated with an increased risk of chronic kidney disease (CKD) in African Americans.

The researchers analysed data for ∼16,000 self-identified African Americans from five US cohorts, including genotype for SCT and measures of kidney function. Primary outcomes were CKD at any time during the study, incident CKD during follow-up, decline in estimated glomerular filtration rate, and albuminuria. The researchers explain that the large sample size and demographic diversity between cohorts enabled adequate power to detect associations and assess their consistency across groups of different age, geographic location and gender.

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References

  • Naik, R. P. et al. Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans. JAMA 10.1001/jama.2014.15063

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  1. Jessica K. Edwards
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Edwards, J. Sickle cell trait increases the risk of chronic kidney disease. Nat Rev Nephrol 11, 65 (2015). https://doi.org/10.1038/nrneph.2014.229

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