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Transplantation

Fc-silent anti-CD40 antibody prolongs allograft survival

Nature Reviews Nephrology volume 11, page 504 (2015)Cite this article

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Blockade of the CD40–CD154 pathway prolongs renal allograft survival in nonhuman primates, but anti-CD154 antibodies are associated with thromboembolic complications and anti-CD40 antibodies are associated with varying degrees of B-cell depletion. To assess the contribution of B-cell depletion to allograft survival, researchers from Novartis Institutes for Biomedical Research assessed the effects of an Fc-silent anti-CD40 monoclonal antibody, CFZ533, in nonhuman primates. CFZ533 was well tolerated and prolonged allograft survival in the absence of B-cell depletion. The researchers suggest this antibody could have therapeutic utility in clinical transplantation.

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References

  1. Cordoba, F. et al. A novel, blocking, Fc-silent anti-CD40 monoclonal antibody prolongs nonhuman primate renal allograft survival in the absence of B cell depletion. Am. J. Transplant. 10.1111/ajt.13377

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Fc-silent anti-CD40 antibody prolongs allograft survival. Nat Rev Nephrol 11, 504 (2015). https://doi.org/10.1038/nrneph.2015.122

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