The constitutive uptake and degradation of filtered albumin by the proximal tubule has resulted in this process being relegated a passive player in albuminuria. Real-time intravital imaging of the rat kidney now describes a new paradigm in which the proximal tubule dynamically increases or decreases albumin uptake following changes in plasma albumin levels.
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References
Haraldsson, B., Nyström, J. & Deen, W. M. Properties of the glomerular barrier and mechanisms of proteinuria. Physiol. Rev. 88, 451–487 (2008).
Russo, L. M. et al. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int. 71, 504–513 (2007).
Sandoval, R. M. et al. Multiple factors influence glomerular albumin permeability in rats. J. Am. Soc. Nephrol. 23, 447–457 (2012).
Birn, H. et al. Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J. Clin. Invest. 105, 1353–1361 (2000).
Zhang, M. Z. et al. CSF-1 signaling mediates recovery from acute kidney injury. J. Clin. Invest. 122, 4519–4532 (2012).
Comper, W. D., Hilliard, L. M., Nikolic-Paterson, D. J. & Russo, L. M. Disease-dependent mechanisms of albuminuria. Am. J. Physiol. Renal Physiol. 295, F1589–F1600 (2008).
Tenten, V. et al. Albumin is recycled from the primary urine by tubular transcytosis. J. Am. Soc. Nephrol. 24, 1966–1980 (2013).
Wagner, M. C. et al. Proximal tubules have the capacity to regulate uptake of albumin. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2014111107.
Slattery, C. et al. In vivo visualization of albumin degradation in the proximal tubule. Kidney Int. 74, 1480–1486 (2008).
Gekle, M. Renal tubule albumin transport. Annu. Rev. Physiol. 67, 573–594 (2005).
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Poronnik, P., Nikolic-Paterson, D. The proximal tubule and albuminuria—at last a starring role. Nat Rev Nephrol 11, 573–575 (2015). https://doi.org/10.1038/nrneph.2015.127
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DOI: https://doi.org/10.1038/nrneph.2015.127
