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Renal injury

Prevention of talin-1-mediated activation of neutrophils protects against renal ischaemia–reperfusion injury

Nature Reviews Nephrology volume 11, page 506 (2015)Cite this article

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Integrins are αβ heterodimeric cell-adhesion molecules that support many biological processes, such as neutrophil-mediated tissue injury in inflammatory disorders. New data from Rodger McEver and colleagues show that the large cytoplasmic protein talin-1 is required for integrin activation in renal ischaemia–reperfusion (I/R) injury and neutrophil arrest along vessel walls.

Talin-1 activates β3 integrins by binding to membrane-distal and membrane-proximal cytoplasmic regions on the integrin β3 subunit, but its effect in mediating the function of the analogous β2 integrin was previously unclear. Here, the investigators questioned whether talin-1 is required to bind the membrane-proximal site on the integrin β2 subunit to enable neutrophil slow rolling and arrest.

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References

  1. Yago, T. et al. Blocking neutrophil integrin activation prevents ischemia–reperfusion injury. J. Exp. Med. 10.1084/jem.20142358

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Authors
  1. Jessica K. Edwards
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Edwards, J. Prevention of talin-1-mediated activation of neutrophils protects against renal ischaemia–reperfusion injury. Nat Rev Nephrol 11, 506 (2015). https://doi.org/10.1038/nrneph.2015.130

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  • DOI: https://doi.org/10.1038/nrneph.2015.130

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