Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Chronic kidney disease

ACR versus UAE

Nature Reviews Nephrology volume 11, page 566 (2015)Cite this article

Subjects

The KDIGO 2012 guidelines state that albuminuria should be assessed using the albumin–creatinine ratio (ACR) rather than by monitoring 24 h urinary albumin excretion (UAE). To assess the importance of misclassification when evaluating albuminuria by ACR in an early morning urine sample instead of 24 h UAE, Vart et al. examined 7,683 participants of the PREVEND and RENAAL studies for reclassification. Only 4.0% participants were reclassified to a higher and 7.9% to a lower albuminuria category when using ACR. Those who were reclassified to a higher ACR category had an increased risk of cardiovascular morbidity and mortality compared to those not reclassified.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Vart, P. et al. Urine albumin-creatinine ratio versus albumin excretion for albuminuria staging: a prospective longitudinal cohort study. Am. J. Kid. Dis. 10.1053/j.ajkd.2015.05.025

Download references

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

ACR versus UAE. Nat Rev Nephrol 11, 566 (2015). https://doi.org/10.1038/nrneph.2015.137

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrneph.2015.137

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing