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Hypertension

Nogo-B regulates BP homeostasis

Nature Reviews Nephrology volume 11, page 631 (2015)Cite this article

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Nogo-B regulates sphingolipid biosynthesis within the endothelium to modulate blood pressure (BP) and could open up new avenues for pharmacologic intervention in hypertension, according to new findings by Annarita Di Lorenzo and colleagues. “The importance of sphingolipid signalling in cardiovascular diseases, including hypertension, has been recognized,” says Di Lorenzo, “but the molecular connection between the sphingolipid pathway and Nogo-B was previously unknown.”

Nogo-B is one of three RTN4 isoforms, and is highly expressed in endothelial cells, whereas Nogo-A and Nogo-C are abundantly expressed in the central nervous system. In their study, the researchers found that Nogo-B might have a specific role in BP homeostasis after observing that mice deficient in Nogo-A and Nogo-B isoforms (Nogo-A/B), both systemically and specifically in endothelial cells, were hypotensive and had elevated sphingolipid levels in endothelial cells compared to controls. The contractility of resistance vessels was maintained.

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References

  1. Cantalupo, A. et al. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat. Med. doi:10.1038/nm.3934

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  1. Jessica K. Edwards
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Edwards, J. Nogo-B regulates BP homeostasis. Nat Rev Nephrol 11, 631 (2015). https://doi.org/10.1038/nrneph.2015.150

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  • DOI: https://doi.org/10.1038/nrneph.2015.150

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