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Hypertension

Lymphocyte adaptor protein puts the 'brakes' on hypertension

Nature Reviews Nephrology volume 11, page 198 (2015)Cite this article

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A recent report by Meena Madhur and colleagues describes a role for lymphocyte adaptor protein (LNK; also known as SH2B3) in angiotensin II (Ang II)-induced hypertension and associated vascular and renal dysfunction. LNK functions as a negative regulator of cytokine signalling and cellular proliferation, but prior to this latest study, how the protein might affect blood pressure (BP) was unknown.

“Our interest in LNK was based on genome-wide association studies that found polymorphisms in LNK to be strongly associated with hypertension as well as autoimmune and cardiovascular disorders,” explains Madhur. “We therefore decided to investigate the role of LNK in hypertension using Lnk−/− mice.”

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References

  1. Saleh, M. A. et al. Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. J. Clin. Invest. 10.1172/JCI176327

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  1. Jessica K. Edwards
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Edwards, J. Lymphocyte adaptor protein puts the 'brakes' on hypertension. Nat Rev Nephrol 11, 198 (2015). https://doi.org/10.1038/nrneph.2015.24

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