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Biomarkers

How precise is NephroCheck®?

Nature Reviews Nephrology volume 11, page 127 (2015)Cite this article

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Recent studies have reported that monitoring urinary concentrations of TIMP-2 and IGFBP7 using the NephroCheck® test (Astute Medical, USA), might serve as an early method to detect acute kidney injury (AKI) following cardiac surgery. However, new data from Onnen Moerer and colleagues suggest that this diagnostic test might not be as precise as originally thought.

The researchers analyzed the accuracy of the multiplied concentrations of urinary TIMP-2 and IGFBP7 (measured using the NephroCheck® test) for early identification of AKI in 42 patients undergoing coronary bypass grafting surgery. Urine samples were analyzed before, immediately after, and 4 h after surgery, and at 8.00 am on the first postoperative day. The biomarker concentrations on the first postoperative day were significantly higher in patients with AKI than in those without AKI, but no between-group differences were found at the earlier time points.

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References

  1. Wetz, A. J. et al. Quantification of urinary TIMP-2 and IGFBP-7—an adequate diagnostic test to predict acute kidney injury after cardiac surgery? Crit. Care 10.1186/s13054-014-0717-4

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  1. Jessica K. Edwards
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Edwards, J. How precise is NephroCheck®?. Nat Rev Nephrol 11, 127 (2015). https://doi.org/10.1038/nrneph.2015.7

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