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Cell biology

Vasopressin-independent AQP2 trafficking

Nature Reviews Nephrology volume 12, page 509 (2016)Cite this article

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“We discovered AKAP220 as a PKA-anchoring protein in 1996,” says Scott. “Our interest in this protein grew with the discovery of more signalling enzyme-binding partners, including PP1 and GSK3, and of a link between the AKAP220 complex and the cytoskeletal scaffold protein IQGAP. Further work showed that elements of the AKAP220 complex confer cAMP-mediated control of cytoskeletal remodelling. The discovery that AKAP220 associates with the AQP2 water pore set the stage for our current study led by Jennifer Whiting.”

deletion of AKAP220 ... resulted in impaired actin-barrier formation and over-accumulation of AQP2

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References

  1. Whiting, J. L. et al. AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc. Natl Acad. Sci. http://dx.doi.org/10.1073/pnas.1607745113 (2016)

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Authors
  1. Ellen F. Carney
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Carney, E. Vasopressin-independent AQP2 trafficking. Nat Rev Nephrol 12, 509 (2016). https://doi.org/10.1038/nrneph.2016.121

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