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Transplantation

Continuous normothermic ex vivo perfusion improves kidney graft function

Nature Reviews Nephrology volume 12, page 580 (2016)Cite this article

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Pressure-controlled continuous normothermic ex vivo kidney perfusion (NEVKP) improves renal graft function in pigs, say researchers. Markus Selzner and colleagues suggest that use of this preservation technique might reduce rates of delayed graft function and improve outcomes in kidney transplantation. “We aim to maintain physiologic conditions during NEVKP,” says Selzner. “The kidneys are kept at 37°C and supplied with nutrition and oxygen using a perfusion solution with erythrocytes and a normal oncotic pressure. The conditions are chosen so that the kidney functions ex vivo as it would in the body.”

NEVKP could result in better quality grafts and might offer the opportunity to assess grafts prior to transplantation

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References

  1. Moritz, K. J. et al. Continuous normothermic ex vivo kidney perfusion improves graft function in donation after circulatory death pig kidney transplantation. Transplantation http://dx.doi.org/10.1097/TP.0000000000001343 (2016)

  2. Moritz, K. J. et al. Eight hour continuous normothermic ex vivo kidney perfusion is a safe preservation technique for kidney transplantation: a new opportunity for the storage, assessment and repair of kidney grafts. Transplantation http://dx.doi.org/10.1097/TP.0000000000001299 (2016)

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  1. Ellen F. Carney
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Carney, E. Continuous normothermic ex vivo perfusion improves kidney graft function. Nat Rev Nephrol 12, 580 (2016). https://doi.org/10.1038/nrneph.2016.128

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  • DOI: https://doi.org/10.1038/nrneph.2016.128

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