Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Diabetic nephropathy

Role of podocyte SHP-1 in hyperglycaemic memory

Nature Reviews Nephrology volume 12, page 650 (2016)Cite this article

Subjects

Access through your institution
Buy or subscribe

New data suggest that sustained expression of podocyte SHP-1 might underlie the long-term renal adverse effects of hyperglycaemia despite normalization of glucose levels in patients with diabetes mellitus.

the progression of microvascular pathology is harder to slow if not treated early in the course of diabetes

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lizotte, F. et al. Persistent insulin resistance in podocytes caused by epigenetic changes of SHP-1 in diabetes. Diabetes http://dx.doi.org/10.2337/db16-0254 (2016)

Download references

Authors
  1. Ellen F. Carney
    View author publications

    Search author on:PubMed Google Scholar

Related links

Related links

Web links

de Boer, I. H. et al. Kidney disease and related findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study. Diabetes Care 37, 24–30 (2014)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Carney, E. Role of podocyte SHP-1 in hyperglycaemic memory. Nat Rev Nephrol 12, 650 (2016). https://doi.org/10.1038/nrneph.2016.140

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrneph.2016.140

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing