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Acute kidney injury

Loss of PKC-ɛ protects against IRI

Nature Reviews Nephrology volume 12, page 714 (2016)Cite this article

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Sudden, temporary interruption of renal blood flow induces ischaemia–reperfusion injury (IRI), a major cause of acute renal failure. A new study conducted by Grazyna Nowak and colleagues shows that deletion of protein kinase C-ɛ (PKC-ɛ) prevents IRI-induced changes in mitochondrial function, kidney morphology and renal function.

The researchers previously showed that blocking the hypoxia or oxidant-induced activation of PKC-ɛ, which mediates mitochondrial dysfunction, in renal proximal tubular cells in vitro protected them from oxidative stress and hypoxic injury. These findings suggested that PKC-ɛ inhibition could protect against IRI in vivo.

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References

  1. Nowak, G. et al. Deletion of protein kinase C-ɛ attenuates mitochondrial dysfunction and ameliorates ischemic renal injury. Am J. Physiol. Renal Physiol. http://dx.doi.org/10.1152/ajprenal.00115.2016 (2016)

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  1. Andrea Aguilar
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Aguilar, A. Loss of PKC-ɛ protects against IRI. Nat Rev Nephrol 12, 714 (2016). https://doi.org/10.1038/nrneph.2016.162

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