Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Hypertension

Microbiota under pressure

Nature Reviews Nephrology volume 13, page 3 (2017)Cite this article

Subjects

Access through your institution
Buy or subscribe

In their study, Mohan Raizada and colleagues found increased permeability and stiffness of the gut barrier, decreased levels of tight junction proteins, increased gut fibrosis, thickening of the gut muscularis layer, decreased villi length and goblet cell loss in spontaneously hypertensive rats (SHR) and in rats with angiotensin II (Ang-II)-induced hypertension. Treatment of SHR with captopril, an angiotensin-converting-enzyme inhibitor, lowered mean arterial pressure, reduced gut permeability, and completely restored fibrosis levels and thickness of the muscularis layer, but did not prevent goblet cell loss and only partially restored villi length.

Treatment of SHR with captopril ... reduced gut permeability and completely restored fibrosis levels and thickness of the muscularis layer

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Santisteban, M. M. et al. Hypertension-linked pathophysiological alterations in the gut. Circ. Res. http://dx.doi.org/10.1161/CIRCRESAHA.116.309006 (2016)

Download references

Authors
  1. Andrea Aguilar
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aguilar, A. Microbiota under pressure. Nat Rev Nephrol 13, 3 (2017). https://doi.org/10.1038/nrneph.2016.173

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrneph.2016.173

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing