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Genetics

Identification of new SLE risk variants

Nature Reviews Nephrology volume 12, page 198 (2016)Cite this article

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Researchers have identified 10 new susceptibility loci and confirmed 20 known susceptibility loci for systemic lupus erythematosus (SLE) in individuals with Asian ancestry. Sun et al. performed a genetic association study in 4,478 patients with SLE and 12,656 control individuals from six East Asian cohorts. Their enrichment analysis showed that functional variants at the newly identified loci alter the expression of genes with roles in B-cell and T-cell biology. The researchers suggest that these loci are potential therapeutic targets for SLE.

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References

  1. Sun, C. et al. High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry. Nat. Genet. http://dx.doi.org/10.1038/ng.3496

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  1. Andrea Aguilar
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Aguilar, A. Identification of new SLE risk variants. Nat Rev Nephrol 12, 198 (2016). https://doi.org/10.1038/nrneph.2016.26

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