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Nanomedicine

Nanocarbon-mediated siRNA delivery to the kidney

Nature Reviews Nephrology volume 12, page 314 (2016)Cite this article

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The development of effective therapeutics based on RNA interference (RNAi) to prevent or treat acute kidney injury (AKI) has been hindered due to confounds such as poor tissue-specific delivery and off-target effects. Now, Michael McDevitt and colleagues report the development of a fibrillar carbon nanomaterial that exhibits tissue-specific and cell-specific pharmacology, which they successfully used as a delivery vehicle for small interfering RNA (siRNA) to target cells of the proximal tubule in mice and silence two genes that are involved in the pathology of AKI.

The fCNT safely mediated delivery of the siRNA cargo to the proximal tubule

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References

  1. Alidori, S. et al. Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury. Sci. Transl. Med. http://dx.doi.org/10.1126/scitranslmed.aac9647

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  1. Jessica K. Edwards
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Ruggiero, A. et al. Paradoxical glomerular filtration of carbon nanotubes. Proc. Natl Acad. Sci. USA 107, 12369–12374 (2010)

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Edwards, J. Nanocarbon-mediated siRNA delivery to the kidney. Nat Rev Nephrol 12, 314 (2016). https://doi.org/10.1038/nrneph.2016.52

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