An algorithm used to evaluate risk in patients with prostate cancer has been improved by taking into account the quantity of risk factors present. The adapted scheme accurately predicts disease-specific mortality, and reveals that prostate cancer is the major cause of death in patients with three or more risk factors.
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References
D'Amico, A. V. et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 280, 969–974 (1998).
Nguyen, P. L. et al. Predicting prostate cancer mortality among men with intermediate to high-risk disease and multiple unfavorable risk factors. Int. J. Radiat. Oncol. Biol. Phys. 73, 659–664 (2009).
Stephenson, A. J. et al. Preoperative nomogram predicting the 10-year probability of prostate cancer recurrence after radical prostatectomy. J. Natl Cancer Inst. 98, 715–717 (2006).
D'Amico, A. V., Renshaw, A. A., Sussman, B. & Chen, M. H. Pretreatment PSA velocity and risk of death from prostate cancer following external beam radiation therapy. JAMA 294, 440–447 (2005).
D'Amico, A. V., Chen, M. H., Roehl, K. A. & Catalona, W. J. Preoperative PSA velocity and the risk of death from prostate cancer after radical prostatectomy. N. Engl. J. Med. 351, 125–135 (2004).
Shariat, S. F. et al. External validation of a biomarker-based preoperative nomogram predicts biochemical recurrence after radical prostatectomy. J. Clin. Oncol. 26, 1526–1531 (2008).
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Isbarn, H., Karakiewicz, P. Improved risk stratification for prostate cancer. Nat Rev Urol 6, 355–356 (2009). https://doi.org/10.1038/nrurol.2009.106
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DOI: https://doi.org/10.1038/nrurol.2009.106