External beam radiation therapy and cryoablation can both be used to treat localized prostate cancer. Quality of life outcomes are similar with the two forms of treatment, with the exception of sexual function, which is poorer in patients treated with cryoablation than in those who receive radiation therapy.
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References
Donnelly, B. J. et al. A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer. Cancer doi:10.1002/cncr.24779.
Robinson, J. W. et al. A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer: quality of life outcomes. Cancer 115, 4695–4704 (2009).
Asterling, S. & Greene, D. R. Prospective evaluation of sexual function in patients receiving cryosurgery as a primary radical treatment for localized prostate cancer. BJU Int. 103, 788–792 (2009).
Chin, J. L. et al. Randomized trial comparing cryoablation and external beam radiotherapy for T2c–T3b prostate cancer. Prostate Cancer Prostatic Dis. 11, 40–45 (2008).
Roach, M. III et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG–ASTRO Phoenix Consensus Conference. Int. J. Radiat. Oncol. Biol. Phys. 65, 965–974 (2006).
Levy, D. A., Pisters, L. L. & Jones, J. S. Primary cryoablation nadir prostate specific antigen and biochemical failure. J. Urol. 182, 931–937 (2009).
Wernicke, A. G., Valicenti, R., Dieva, K., Houser, C. & Pequignot, E. Radiation dose delivered to the proximal penis as a predictor of the risk of erectile dysfunction after three-dimensional conformal radiotherapy for localized prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 60, 1357–1363 (2004).
Roach, M. et al. Penile bulb dose and impotence after three-dimensional conformal radiotherapy for prostate cancer on RTOG 9406: findings from a prospective, multi-institutional, phase I/II dose-escalation study. Int. J. Radiat. Oncol. Biol. Phys. 60, 1351–1356 (2004).
Mangar, S. A. et al. Evaluating the relationship between erectile dysfunction and dose received by the penile bulb: using data from a randomised controlled trial of conformal radiotherapy in prostate cancer (MRC RT01, ISRCTN47772397). Radiother. Oncol. 80, 355–362 (2006).
Speight, J. L. & Roach, M. III. Advances in the treatment of localized prostate cancer: the role of anatomic and functional imaging in men managed with radiotherapy. J. Clin. Oncol. 25, 987–995 (2007).
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Roach, M. Worse sexual function after cryoablation—a case for EBRT?. Nat Rev Urol 7, 122–124 (2010). https://doi.org/10.1038/nrurol.2010.11
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DOI: https://doi.org/10.1038/nrurol.2010.11
