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Does the dose intensity of BEP chemotherapy affect survival?

Nature Reviews Urology volume 7, page 477 (2010)Cite this article

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Most patients with metastatic germ cell tumors (GCTs) are considered to have a good prognosis: cure rates >90% have been reported since the introduction of bleomycin, etoposide and cisplatin (BEP) chemotherapy regimens. Several studies have since attempted to reduce the toxicity associated with these regimens while maintaining high rates of cure.

In 2001, the Australian and New Zealand Germ Cell Trials Group (ANZGCTG) published the results of their study that compared two standard BEP regimens—a four-cycle, less-dose-intense regimen and a three-cycle, more-dose-intense regimen—in 166 patients with good-prognosis metastatic GCT according to the modified Memorial Sloan–Kettering criteria. The group has now reported an updated analysis of the long-term survival rates and adverse effects associated with these two BEP regimens.

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ORIGINAL RESEARCH PAPER

  1. Grimison, P. S. et al. Comparison of two standard chemotherapy regimens for good-prognosis germ cell tumors: updated analysis of a randomized trial. J. Natl Cancer Inst. doi:10.1093/jnci/djq245

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  1. Nick Warde
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Warde, N. Does the dose intensity of BEP chemotherapy affect survival?. Nat Rev Urol 7, 477 (2010). https://doi.org/10.1038/nrurol.2010.127

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  • DOI: https://doi.org/10.1038/nrurol.2010.127

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