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Prostate cancer

The promise of psychostimulants for disease-related fatigue

Nature Reviews Urology volume 7, page 478 (2010)Cite this article

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The first randomized placebo-controlled trial of a psychostimulant for prostate cancer-related fatigue has generated encouraging preliminary results. Despite the difficulty they experienced recruiting participants, the study team remains upbeat about the potential of drugs of this type to improve patients' quality of life.

Up to 70% of men with prostate cancer are distressed by excessive tiredness. Andrew Roth and colleagues therefore assumed that enrolling 120 ambulatory patients from the 1,000-plus being treated at Memorial Sloan–Kettering Cancer Center in New York was a realistic goal.

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ORIGINAL RESEARCH PAPERS

  1. Roth, A. J. et al. Methylphenidate for fatigue in ambulatory men with prostate cancer. Cancer doi:10.1002/cncr.25424

  2. Moraska, A. R. et al. Phase III, randomized, double-blind, placebo-controlled trial of long-acting methylphenidate for cancer-related fatigue: North Central Cancer Treatment Group NCCTG-N05C7 trial. J. Clin. Oncol. doi:10.1200/JCO.2010.28.1444

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  1. Suzanne J. Farley
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Farley, S. The promise of psychostimulants for disease-related fatigue. Nat Rev Urol 7, 478 (2010). https://doi.org/10.1038/nrurol.2010.136

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